selected publications
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academic article
- Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127). Journal of medicinal chemistry. 57:1845-1854. 2014
- Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase — Acylsulfonamides and acylsulfamides as carboxylic acid replacements. Canadian journal of chemistry. 91:66-81. 2013
- Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay. Bioorganic & medicinal chemistry letters. 23:6879-6885. 2013
- Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorganic & medicinal chemistry letters. 23:2585-2589. 2013
- Novel Inhibitor Binding Site Discovery on HIV-1 Capsid N-Terminal Domain by NMR and X-ray Crystallography. ACS chemical biology. 8:1074-1082. 2013
- Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: Structure–activity relationships (SAR) of the C3-phenyl moiety. Bioorganic & medicinal chemistry letters. 23:3401-3405. 2013
- Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein. Journal of virology. 86:6643-6655. 2012
- Biphenylsulfonacetic Acid Inhibitors of the Human Papillomavirus Type 6 E1 Helicase Inhibit ATP Hydrolysis by an Allosteric Mechanism Involving Tyrosine 486. Antimicrobial agents and chemotherapy. 49:4834-4842. 2005
- Inhibitors of Respiratory Syncytial Virus Replication Target Cotranscriptional mRNA Guanylylation by Viral RNA-Dependent RNA Polymerase. Journal of virology. 79:13105-13115. 2005
- A Systematic Approach to the Optimization of Substrate-Based Inhibitors of the Hepatitis C Virus NS3 Protease: Discovery of Potent and Specific Tripeptide Inhibitors. Journal of medicinal chemistry. 47:6584-6594. 2004
- Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase. Journal of medicinal chemistry. 47:18-21. 2004
- Peptide-Based Inhibitors of the Hepatitis C Virus NS3 Protease: Structure−Activity Relationship at theC-Terminal Position. Journal of medicinal chemistry. 47:2511-2522. 2004
- Erratum: An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature. 426:186-189. 2003
- Erratum: Corrigendum: An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature. 426:314-314. 2003
- Nonpeptidic, Monocharged, Cell Permeable Ligands for the p56lck SH2 Domain. Journal of medicinal chemistry. 44:2421-2431. 2001
- Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors. Bioorganic & medicinal chemistry letters. 10:2267-2270. 2000
- Ligands for the Tyrosine Kinase p56lckSH2 Domain: Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements. Journal of medicinal chemistry. 42:1757-1766. 1999
- Phosphotyrosine-Containing Dipeptides as High-Affinity Ligands for the p56lckSH2 Domain. Journal of medicinal chemistry. 42:722-729. 1999
- Generation of glycinyl radicals via a 1,5-hydrogen atom transfer reaction. Applications to γ-lactam formation. Tetrahedron letters. 39:5339-5342. 1998
- Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease. Bioorganic & medicinal chemistry letters. 8:2719-2724. 1998
- Role of .sigma.-Donation in the Stereocontrol of Hydrogen-Transfer Reactions Involving Acyclic Radicals. The Journal of organic chemistry. 60:288-289. 1995
- Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin. The Journal of organic chemistry. 59:1166-1178. 1994
- Cyclopropanation in vinyl radical cyclizations: The importance of structural constraints.. Tetrahedron letters. 34:2091-2094. 1993
- The effect of polar substituents on the conformation and stereochemistry of enolate radicals. Tetrahedron letters. 34:5885-5888. 1993
- Stereoselective hydrogen-transfer reactions involving acyclic radicals. A study of radical conformations using semiempirical calculations. Journal of the American Chemical Society. 114:4912-4914. 1992
- Stereoselective chelation-controlled reduction of .alpha.-iodo-.beta.-alkoxy esters under radical conditions. Journal of the American Chemical Society. 113:9701-9702. 1991
- Tetrahydropyran synthesis via radical cyclization. A systematic study of substituent effects. Journal of the American Chemical Society. 113:2335-2336. 1991
- Chiral synthetic macrodiolide and macrotriolide ionophores with C2- and C2symmetry. Tetrahedron letters. 31:5285-5288. 1990
- Total regiospecific synthesis of the selagine tricyclic ring system. Canadian journal of chemistry. 62:2945-2947. 1984